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دانلود کتاب Biobetters-مهندسی پروتئین به رویکرد درمانی

دانلود کتاب Biobetters-مهندسی پروتئین به رویکرد درمانی

Biobetters – Protein Engineering to Approach the Curative

دانلود کتاب Biobetters-مهندسی پروتئین به رویکرد درمانی

نویسنده: Amy Rosenberg, Barthelemy Demeule

ویرایش: 1

سال انتشار: 2015

قیمت در آمازون: 209 دلار

تعداد صفحات: 384

نوع فایل: pdf

 

توضیحات کتاب در آمازون

“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases.

It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles.

Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs.

Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile.

 Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were.

For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages.

For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases.

Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics.

This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death.

Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment.

The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective.

This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy.

 These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use.

The economics surrounding the issue of biobetters is another high-profile issue – this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.


دانلود کتاب Biobetters-مهندسی پروتئین به رویکرد درمانی

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دانلود کتاب کاربرد های زیست پزشکی پروتئین های طبیعی

دانلود کتاب کاربرد های زیست پزشکی پروتئین های طبیعی

Biomedical Applications of Natural Proteins – An Emerging Era in Biomedical Sciences

دانلود کتاب کاربرد های زیست پزشکی پروتئین های طبیعی

نویسنده: Dhiraj Kumar, Rajesh R. Kundapur

ویرایش: 1

سال انتشار: 2015

تعداد صفحات: 158

قیمت در آمازون: 54 دلار

نوع فایل: pdf

 

توضیحات کتاب در آمازون

This book is intended as a reference guide for graduate students, postgraduate students and researchers with a basic knowledge of protein chemistry who would like to know more about the biomedical applications of natural proteins to promote healthier lives.

The book is divided into ten chapters, each of which explains different natural proteins and their established biomedical applications. The first chapter extensively deals with protein based natural fibers and provides an overview of all protein based fibers currently available.  In turn, chapter two mainly focuses on the biomedical applications of a special class of proteins called Heat Shock Proteins; the biomedical applications of silkworm pupae proteins are dealt in chapter three. Chapter four examines an interesting use of Eri silk fibroin as a biomaterial for Tissue Engineering, while chapter five discusses the key experimental details involved in converting Tasar silk sericin into self-assembled nanoparticles. Chapter six offers brief descriptions of bioactive proteins with respect to their sources, synthesis and applications. Chapter seven is dedicated to Interleukine-8 and its role in human life, while chapter eight addresses the importance of natural proteins in infectious diseases. Chapter nine explores the issue of excess intake of dietary proteins and its adverse effects, and finally, chapter ten discusses the efficiency of drug delivery systems made up of gelatin nanocomposites.

The book is above all intended as a valuable resource for students and researchers alike, sparking their curiosity with regard to the applications of natural proteins and motivating them to focus their own energies on the discovery or identification of additional natural proteins for diverse biomedical uses.


دانلود کتاب کاربرد های زیست پزشکی پروتئین های طبیعی

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دانلود کتاب ویتامین ها-The Vitamins-Fundamental Aspects in Nutrition and Health

دانلود کتاب ویتامین ها-The Vitamins-Fundamental Aspects in Nutrition and Health

دانلود کتاب ویتامین ها-The Vitamins-Fundamental Aspects in Nutrition and Health

نویسنده: (by Gerald F. Combs Jr. (Author

سال انتشار: 2007

ویرایش: 3

تعداد صفحات: 603

نوع فایل: pdf

قیمت در آمازون: 37 دلار


The third edition of this bestselling text will again provide the latest coverage of the biochemistry and physiology of vitamins and vitamin-like substances. Extensively revised and expanded on the basis of recent research findings with enlarged coverage of health effects of vitamin-like factors, it is ideally suited for students and an important reference for anyone interested in nutrition, food science, animal science or endocrinology. It contains a cohesive and well-organized presentation of each of the vitamins, as well as the history of their discoveries and current information about their roles in nutrition and health.

NEW TO THIS EDITION:
– Includes approximately 30% new material
– Substantial updates have been made to chapters on vitamins A, C, E, K, folate, and the quasi-vitamins
– Provides checklists of systems affected by vitamin deficiencies and food sources of vitamins
– Key concepts, learning objectives, vocabulary,case studies, study questions and additional reading lists are included making this ideally suited for students
– Thoroughly updated with important recent research results, including citations to key reports, many added tables and several new figures.
– Addition of Health and Nutrition Examination Survey (HANES III) data


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کتاب زیست شناسی سلولی مولکولی لودیش-pdf

کتاب زیست شناسی سلولی مولکولی لودیش-pdf

کتاب زیست شناسی سلولی مولکولی لودیش-pdf

يكي از بهترين و كاملترين مجموعه كتاب هاي منتشر شده در زمينه زيست شناسي سلولي و مولكولي مي باشد.اين كتاب يكي از رفرنس هاي كارشناسي ارشد و دكتري مي باشد.

With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, Molecular Cell Biology has justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors

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